د مقالې جانبي پينل
د مقالې اصلي محتوا
خلاصه
امینو اسیدها واحدهای ساختمانی تمامی پپتایدها و پروتئینهای اند که بسیاری از خواص مهم فزیولوژیکی آنها را تعیین مینمایند. امینو اسیدها در تجزیه غذا، رشد و ترمیم انساج بدن، ساخت هورمون، منبع انرژی، نگهداری سالم پوست، مو و ناخن، عضلهسازی و تقویت سیستم ایمنی بدن کمک میکنند. بیش از ۵۰۰ نوع امینو اسیدهای مختلف در طبیعت شناخته شده است، اما تنها 20 نوع آنها در ترکیب و سنتز پروتئین سهم میگیرند. تعیین ترتیب و تسلسل امینو اسیدها در یک پروتئین یا پپتاید اطلاعات مفیدی جهت درک ساختمان و فعالیتهای فزیولوژیکی آنها ارایه مینماید. در این مقالهی مروری، روشهای کیمیاوی مختلف مانند تجزیه ادمن، سنگــر و همچنین معرفهــای کیمیاوی مختلف مانند ننهایدرین، کاربوکســی پپتایداز و هــایدرازین برای شناسایی ترکیب و تسلسل امینو اسیدها در مالیکولهای پروتئین به بررسی گرفته شده اند.
کلیدي ټکي
د مقالې جزئیات
د کاپی رایت بیان
د کرییټیو کامنز BY-NC 4.0 نړیوال لایسنسماخذونه
- Akram M, Asif HM, Uzair M, Akhtar N, Madni A, Shah SA, Hasan ZU, Ullah A. Amino acids: A review article. J. Med. Plants Res. 2011;5(17):3997-4000.
- Kamble C, Chavan R, Kamble V. A Review on Amino Acids. J. Drug Des. Discov. 2021; 8(3):19–27.
- Larsen PO. Physical and chemical properties of amino acids. The Biochemistry of Plants: A Comprehensive Treatise, Amino Acids and Derivatives. 1980; 5(8):225-269.
- Bischoff R, Schlüter H. Amino acids: chemistry, functionality and selected non-enzymatic post-translational modifications. J. Proteomics. 2012; 75(8):2275-2296.
- Wu G. Amino acids: metabolism, functions, and nutrition. Amino acids. 2009; 37(1):1-7.
- Liljas A, Ehrenberg M. Structural aspects of protein synthesis, 2nd ed. World Scientific. 2013.
- Solomons G, Fryhle CB, Snyder SA. Organic Chemistry: Amino acids and proteins, 11th ed. John Wiley & Sons. 2014:1060-1071.
- Garrett RH, Grisham CM. Biochemistry. Cengage Learning. 2016:77-101.
- Sanger F. Sequences, sequences, and sequences. Annu Rev Biochem. 1988; 57(1):1–29.
- Han KK, Belaiche D, Moreau O, Briand G. Current developments in stepwise edman degradation of peptides and proteins. International Journal of Biochemistry. 1985; 17(4):429–45.
- Loos T, Mortier A, Proost P. Isolation, identification, and production of posttranslationally modified chemokines. Methods Enzymol. 2009; 461:3–29.
- Qian Z, Upadhyaya P, Pei D. Synthesis and screening of one-bead-one-compound cyclic peptide libraries. Peptide Libraries: Methods and Protocols. 2015; 39–53.
- Mann M. The rise of mass spectrometry and the fall of Edman degradation. Clin Chem. 2016; 62(1):293–4.
- Wade JL, Simek JW. Organic Chemistry, 9th ed. Pearson Education India. 2017.
- Bhagavan NV. Medical biochemistry. Academic press. 2002.
- Friedman M. Applications of the ninhydrin reaction for analysis of amino acids, peptides, and proteins to agricultural and biomedical sciences. J. Agric. Food Chem. 2004; 52(3):385-406.
- Nguyen DN, Becker GW, Riggin RM. Protein mass spectrometry: applications to analytical biotechnology. J. Chromatogr. A. 1995; 705(1):21-45.
- Needleman SB, editor. Protein sequence determination: a sourcebook of methods and techniques. Springer Science & Business Media; 2012.
- David L. Lehninger principles of biochemistry. 2008.
- (20) Walker JM. The dansyl method for identifying N-terminal amino acids. Methods Mol Biol. 1984; 1:203-2012.
ماخذونه
Akram M, Asif HM, Uzair M, Akhtar N, Madni A, Shah SA, Hasan ZU, Ullah A. Amino acids: A review article. J. Med. Plants Res. 2011;5(17):3997-4000.
Kamble C, Chavan R, Kamble V. A Review on Amino Acids. J. Drug Des. Discov. 2021; 8(3):19–27.
Larsen PO. Physical and chemical properties of amino acids. The Biochemistry of Plants: A Comprehensive Treatise, Amino Acids and Derivatives. 1980; 5(8):225-269.
Bischoff R, Schlüter H. Amino acids: chemistry, functionality and selected non-enzymatic post-translational modifications. J. Proteomics. 2012; 75(8):2275-2296.
Wu G. Amino acids: metabolism, functions, and nutrition. Amino acids. 2009; 37(1):1-7.
Liljas A, Ehrenberg M. Structural aspects of protein synthesis, 2nd ed. World Scientific. 2013.
Solomons G, Fryhle CB, Snyder SA. Organic Chemistry: Amino acids and proteins, 11th ed. John Wiley & Sons. 2014:1060-1071.
Garrett RH, Grisham CM. Biochemistry. Cengage Learning. 2016:77-101.
Sanger F. Sequences, sequences, and sequences. Annu Rev Biochem. 1988; 57(1):1–29.
Han KK, Belaiche D, Moreau O, Briand G. Current developments in stepwise edman degradation of peptides and proteins. International Journal of Biochemistry. 1985; 17(4):429–45.
Loos T, Mortier A, Proost P. Isolation, identification, and production of posttranslationally modified chemokines. Methods Enzymol. 2009; 461:3–29.
Qian Z, Upadhyaya P, Pei D. Synthesis and screening of one-bead-one-compound cyclic peptide libraries. Peptide Libraries: Methods and Protocols. 2015; 39–53.
Mann M. The rise of mass spectrometry and the fall of Edman degradation. Clin Chem. 2016; 62(1):293–4.
Wade JL, Simek JW. Organic Chemistry, 9th ed. Pearson Education India. 2017.
Bhagavan NV. Medical biochemistry. Academic press. 2002.
Friedman M. Applications of the ninhydrin reaction for analysis of amino acids, peptides, and proteins to agricultural and biomedical sciences. J. Agric. Food Chem. 2004; 52(3):385-406.
Nguyen DN, Becker GW, Riggin RM. Protein mass spectrometry: applications to analytical biotechnology. J. Chromatogr. A. 1995; 705(1):21-45.
Needleman SB, editor. Protein sequence determination: a sourcebook of methods and techniques. Springer Science & Business Media; 2012.
David L. Lehninger principles of biochemistry. 2008.
(20) Walker JM. The dansyl method for identifying N-terminal amino acids. Methods Mol Biol. 1984; 1:203-2012.