Main Article Content

Abstract

Clostridium botulinum is an important pathogenic agent that produces seven types of neurotoxins (A-G) and causes severe and fatal disease in different hosts including humans. Beside its pathogenesis, recent studies shows the effectiveness of these toxins for treatment of many disorders of humans in low doses. In this review article, the latest published scientific articles about effectiveness of the mentioned bacterial toxins in the treatment of some specific conditions in humans have been reviewed and their specific results have been used. The results of various studies show that in addition to the severe and lethal properties of Clostridium botulinum toxins, a number of these toxins, especially type A and B (especially Botox) have wide therapeutic uses and, is used for the treatment of various disorders in humans, which is cheap, safe and effective compared to other methods, and it is easy to apply.

Keywords

Clostridium botulinum Toxin botulism disorders acetylcholine

Article Details

How to Cite
Neyazi, A. J. (2025). A Review of the Therapeutic Properties of Clostridium Botulinum Toxins. Journal of Natural Sciences – Kabul University, 6(1), 213–222. https://doi.org/10.62810/jns.v6i1.316

References

  1. Al-ghamdi AS, Alghanemy N, Joharji H, Al-qahtani D, Alghamdi H. ScienceDirect Botulinum toxin : Non cosmetic and off-label dermatological uses. J Dermatology Dermatologic Surg [Internet]. 2015;19(1):1–8. Available from: http://dx.doi.org/10.1016/j.jdds.2014.06.002
  2. Carr WW, Jain N, Sublett JW. Immunogenicity of Botulinum Toxin Formulations: Potential Therapeutic Implications. Adv Ther [Internet]. 2021;38(10):5046–64. Available from: https://doi.org/10.1007/s12325-021-01882-9
  3. Kant V, Koshal R, Kumar Verma P, Pankaj NK. Therapeutic and Cosmetic uses of Botulinum Toxin. 2009;4(1). Available from: www.vetscan.co.in
  4. Nigam P, Nigam A. Botulinum toxin. Indian J Dermatol. 2010;55(1):8–14.
  5. Becker WJ. Botulinum Toxin in the Treatment of Headache. 2020;
  6. Persaud R, Garas G, Silva S, Stamatoglou C, Chatrath P, Patel K. An evidence-based review of botulinum toxin (Botox) applications in non-cosmetic head and neck conditions. JRSM Short Rep. 2013;4(2):1–9.
  7. Shaterian N, Shaterian N, Ghanaatpisheh A, Abbasi F, Daniali S, Jahromi MJ, et al. Botox ( OnabotulinumtoxinA ) for Treatment of Migraine Symptoms : A Systematic Review. 2022;2022:1–15.
  8. Jabbari B, Lakraj AAD, Moghimi N. Hyperhidrosis: Anatomy, pathophysiology and treatment with emphasis on the role of botulinum Toxins. Toxins (Basel). 2013;5(4):821–40.
  9. Doft MA, Hardy KL, Ascherman JA. Treatment of Hyperhidrosis With Botulinum Toxin. 2012;
  10. Muraro CSP, Marques SDA, Rocha-lima ABC, Oliveira AG De, Lopes ÉS, Aparecido CTR, et al. Botulinum Toxin Type A in the Treatment of Hyperhidrosis : Case Study Botulinum Toxin Type A in the Treatment of Hyperhidrosis : Case Study. 2019;(May).
  11. Tambasco N, Filidei M, Nigro P, Parnetti L, Simoni S. Botulinum toxin for the treatment of hemifacial spasm: An update on clinical studies. Toxins (Basel). 2021;13(12):1–11.
  12. Gil Polo C, Rodríguez Sanz MF, Berrocal Izquierdo N, Castrillo Sanz A, Gutiérrez Ríos R, Zamora García MI, et al. Blepharospasm and hemifacial spasm: Long-term treatment with botulinum toxin. Neurol (English Ed [Internet]. 2013;28(3):131–6. Available from: http://dx.doi.org/10.1016/j.nrleng.2012.03.016
  13. Hemaidi SS Al, Sesma G, Ahmad K, Alghofaili RS, Awad RA. Efficacy of Botulinum Toxin Injection in Exotropia Treatment. 2021;
  14. Bonaffini SG, Cocozza V, Jin J. BOTOX injection to treat strabismus after infant botulism type B infection. Am J Ophthalmol Case Reports [Internet]. 2020;20:100895. Available from: https://doi.org/10.1016/j.ajoc.2020.100895
  15. Teo L, Chee E. Uses of botulinum toxin a in ophthalmology. Proc Singapore Healthc. 2012;21(1):30–9.
  16. Satriyasa BK. Botulinum toxin (Botox) a for reducing the appearance of facial wrinkles: A literature review of clinical use and pharmacological aspect. Clin Cosmet Investig Dermatol. 2019;12:223–8.
  17. Silva MCP da, Rodrigues CM de C, Figueiredo CE, Reis DCS dos, Almeida VL de, Cardoso SV, et al. Effect of botulinum toxin treatment in patients with bruxism and orofacial pain - randomized double-blind clinical trial. Res Soc Dev. 2020;9(9):e917998206.
  18. Fernández-Núñez T, Amghar-Maach S, Gay-Escoda C. Efficacy of botulinum toxin in the treatment of bruxism: Systematic review. Med Oral Patol Oral y Cir Bucal. 2019;24(4):e416–24.