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Abstract
In this article, the biological properties of thiosemicarbazone ligands and their respective transition metal complexes are discussed. The biological activities of the aforementioned compounds are related to their unique structural properties, the nature of ligands and transition metals, and the presence of different substituents in the respective compounds of aldehyde, ketone, and thiosemicarbazide. The biological properties of thiosemicarbazones compared to standard drugs are generally evaluated using different methods such as real-time cell electronic sensing (RT-CES), MTT, and CUPRAC, and the results are included in tables and graphs. In this article, a review method with a descriptive-analytical approach is used, the results of which show more activity of the complexes compared to the primary ligands.
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References
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References
) Piri Z, Shoeili ZM, Assoud A. New copper (II) complex with bioactive 2– acetylpyridine-4N-p-chlorophenylthiosemicarbazone ligand: Synthesis, X-ray structure, and evaluation of antioxidant and antibacterial activity. Inorganic Chemistry Communications. 2017; 84: 122 –126.
Yuan J, Lovejoy DB, Richardson DR. Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment. Blood. 2004; 104: 1450–1458.
Kannan S, Sivagamasundari M, Ramesh R, Liu Yu. Ruthenium(II) carbonyl complexes of dehydroacetic acid thiosemicarbazone: Synthesis, structure, light emission and biological activity. Journal of Organometallic Chemistry. 2008; 693: 2251–2257.
Azarkish M, Akbari A, Sedaghat T, Simpson J. Ternary complexes of Zn(II) and Cu(II) with 1-((2-hydroxynaphthalen- 1-yl)methylene)-4-phenylthiosemicarbazide in the presence of heterocyclic bases as auxiliary ligands: Synthesis, spectroscopic and structural characterization and antibacterial activity. Journal of Molecular Structure. 2018; 1156: 34–42.
Fonteh PN, Keter FK, Meyer D. New bis(thiosemicarbazonate) gold(III) complexes inhibit HIV replication at cytostatic concentrations: Potential for incorporation into virostatic cocktails. Journal of Inorganic Biochemistry. 2011; 105: 1173–1180.
Mir JM, Jain N, Jaget PS, Khan W, Vishwakarma PK, Rajak DK, Malik BA, Maurya RC. Urinary tract anti-infectious potential of DFT-experimental composite analyzed ruthenium nitrosyl complex of N-dehydroacetic acid- thiosemicarbazide. Journal of King Saud University – Science. 2019; 31: 89–100.
Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. Journal of Inorganic Biochemistry. 2010; 104: 1079–1083.
Khanye SD, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Smith GS, Chibale K. Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands. Journal of Organometallic Chemistry. 2011; 696: 3392– 3396.
Kalındemirtaş FD, Kaya B, Bener M, Şahin O, Kuruca SE, Demirci TB, Ülküseven B. Synthesis, characterization, radical scavenging activity and in vitro cytotoxicity on K562, P3HR1 and JURKAT. Appllied Organometallic Chemistry. 2021; 35: 6157.
Özerkan D, Ertik O, Kaya B, Kuruca SE, Yanardağ R, Ülküseven B. Novel palladium (II) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, in vitro cytotoxicity and xanthine oxidase inhibition. Investigational New Drugs. 2019; 37: 1187–1197.
Balakrishnan N, Haribabu J, Krishnan DA, Swaminathan S, Mahendiran D, Bhuvanesh NSP, Karvembu R. Zinc(II) complexes of indole thiosemicarbazones: DNA/protein binding, molecular docking and in vitro cytotoxicity studies. Polyhedron. 2019; 170: 188–201.
Demirci TB, Şahin M, Özyürek M, Kondakcı E, Ülküseven B. Synthesis, antioxidant activities of the nickel(II), iron(III) and oxovanadium(IV) complexes with N2O2 chelating thiosemicarbazones. Spectrochimica Acta Part A. 2014; 126: 317–323.