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Abstract

Transferosomes are highly flexible and deformable vesicular carriers that have attracted considerable attention as promising systems for transdermal drug delivery. They are mainly composed of phospholipids, surfactants, and water. Their remarkable deformability enables them to pass through very small pores and intercellular pathways in the skin while maintaining structural integrity, facilitating the delivery of active pharmaceutical ingredients into deeper skin layers and, in some cases, systemic circulation. This review examines the composition, mechanisms, applications, advantages, and limitations of transferosomes in transdermal drug delivery. Surfactants enhance skin permeation by reducing interfacial tension and increasing vesicular flexibility and deformability. Consequently, transferosomes can effectively deliver both hydrophilic and lipophilic drugs, potentially improving bioavailability and reducing the need for oral administration. They have shown promising applications in delivering anti-inflammatory, antimicrobial, and anticancer drugs, as well as hormones, peptides, proteins, and other biologically active compounds. They may also provide controlled drug release and protect drugs from degradation. Despite these advantages, challenges include physical and chemical instability, drug leakage, difficulties in large-scale manufacturing, and limited clinical evidence. Further research is required to optimize formulations, improve stability, evaluate long-term safety, and confirm clinical efficacy, reproducibility, and therapeutic potential.

Keywords

Drug Nano Particle Skin Permeation Transdermal Drug Delivery Transferosomes

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Yousofzai, R., Zhakfar, A. M., & Raihan, R. (2026). The Role of Transferosomes in Enhancing Transdermal Drug Delivery. Journal of Natural Sciences – Kabul University, 9(2), 159–178. https://doi.org/10.62810/jns.v9i2.578
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References

  1. Ahmed, T. A. (2015). Preparation of transfersomes encapsulating sildenafil aimed for transdermal drug delivery: Plackett–Burman design and characterization. Journal of Liposome Research, 25(1), 1–10. https://doi.org/10.3109/08982104.2014.950276 DOI: https://doi.org/10.3109/08982104.2014.950276
  2. Asadujjaman, M., & Mishuk, A. U. (2013). NOVEL APPROACHES IN LIPID BASED DRUG DELIVERY SYSTEMS. Journal of Drug Delivery and Therapeutics, 3(4). https://doi.org/10.22270/jddt.v3i4.578 DOI: https://doi.org/10.22270/jddt.v3i4.578
  3. Atlan, M., & Neman, J. (2019). Targeted transdermal delivery of curcumin for breast cancer prevention. International Journal of Environmental Research and Public Health, 16(24), 4949. https://doi.org/10.3390/ijerph16244949 DOI: https://doi.org/10.3390/ijerph16244949
  4. Baldino, L., & Reverchon, E. (2021). Niosomes formation using a continuous supercritical CO2 assisted process. Journal of CO2 Utilization, 52, 101669. https://doi.org/10.1016/j.jcou.2021.101669 DOI: https://doi.org/10.1016/j.jcou.2021.101669
  5. Bhujbal, S., Rupenthal, I. D., & Agarwal, P. (2025). Evaluation of ocular tolerability and bioavailability of tonabersat transfersomes ex vivo. Drug Delivery and Translational Research, 16(4), 1222–1232. https://doi.org/10.1007/s13346-025-01872-2 DOI: https://doi.org/10.1007/s13346-025-01872-2
  6. Bnyan, R., Khan, I., Ehtezazi, T., Saleem, I., Gordon, S., O’Neill, F., & Roberts, M. (2019). Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic. Journal of Pharmacy and Pharmacology, 71(10), 1508–1519. https://doi.org/10.1111/jphp.13149 DOI: https://doi.org/10.1111/jphp.13149
  7. Brito, S., Baek, M., & Bin, B. H. (2024). Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery. Pharmaceutics, 16(11), 2024. https://doi.org/10.3390/pharmaceutics16111403 DOI: https://doi.org/10.3390/pharmaceutics16111403
  8. Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochimica et Biophysica Acta (BBA) – Biomembranes. 1992;1104(1):226–232. doi:10.1016/0005-2736(92)90154-E. https://doi.org/10.1016/0005-2736(92)90154-E DOI: https://doi.org/10.1016/0005-2736(92)90154-E
  9. Chaurasia, L., Singh, S., Arora, K., & Saxena, C. (2019). Transferosome: a SuitableDelivery System for percutaneous administration. Current Research in Pharmaceutical Sciences, 9(1), 1–11. https://doi.org/10.24092/crps.2019.090101 DOI: https://doi.org/10.24092/CRPS.2019.090101
  10. Chen, M., Liu, X., & Fahr, A. (2011). Skin penetration and deposition of carboxyfluorescein and temoporfin from different lipid vesicular systems: In vitro study with finite and infinite dosage application. International Journal of Pharmaceutics, 408(1–2), 223–234. https://doi.org/10.1016/j.ijpharm.2011.02.006 DOI: https://doi.org/10.1016/j.ijpharm.2011.02.006
  11. Croitoru, G., Niculescu, A., Epistatu, D., Mihaiescu, D. E., Antohi, A. M., Grumezescu, A. M., & Nicolae, C. (2024). Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations. Applied Sciences, 14(19), 8948. https://doi.org/10.3390/app14198948 DOI: https://doi.org/10.3390/app14198948
  12. Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018). Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics, 10(2), 57. https://doi.org/10.3390/pharmaceutics10020057 DOI: https://doi.org/10.3390/pharmaceutics10020057
  13. El-Alim, S. H. A., Kassem, A. A., Basha, M., & Salama, A. (2019). Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: In vitro and in vivo evaluation. International Journal of Pharmaceutics, 563, 293–303. https://doi.org/10.1016/j.ijpharm.2019.04.001 DOI: https://doi.org/10.1016/j.ijpharm.2019.04.001
  14. Garg, J., Pathania, K., Sah, S. P., & Pawar, S. V. (2022). Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours. Future Journal of Pharmaceutical Sciences, 8(1). https://doi.org/10.1186/s43094-022-00414-8 DOI: https://doi.org/10.1186/s43094-022-00414-8
  15. Goyal, A., et al. (2023). Transferosomes: A novel nanotechnological approach for transdermal drug delivery. In Advanced and Modern Approaches for Drug Delivery (pp. 199–221). https://doi.org/10.1016/B978-0-323-91668-4.00017-4 DOI: https://doi.org/10.1016/B978-0-323-91668-4.00017-4
  16. Javed, S., Mangla, B., Almoshari, Y., Sultan, M. H., & Ahsan, W. (2022). Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery. Nanotechnology Reviews, 11(1), 1744–1777. https://doi.org/10.1515/ntrev-2022-0109 DOI: https://doi.org/10.1515/ntrev-2022-0109
  17. Martinho, N., Damgé, C., & Reis, C. P. (2011). Recent advances in drug delivery systems. Journal of Biomaterials and Nanobiotechnology, 02(05), 510–526. https://doi.org/10.4236/jbnb.2011.225062 DOI: https://doi.org/10.4236/jbnb.2011.225062
  18. Matei, A., Caruntu, C., Tampa, M., Georgescu, S. R., Matei, C., Constantin, M. M., Constantin, T. V., Calina, D., Ciubotaru, D. A., Badarau, I. A., Scheau, C., & Caruntu, A. (2021). Applications of Nanosized-Lipid-Based drug delivery systems in wound care. Applied Sciences, 11(11), 4915. https://doi.org/10.3390/app11114915 DOI: https://doi.org/10.3390/app11114915
  19. Mozafari, M. R., Mazaheri, E., & Dormiani, K. (2021). Simple equations pertaining to the particle number and surface area of metallic, polymeric, lipidic and vesicular nanocarriers. Scientia Pharmaceutica, 89(2), 15. https://doi.org/10.3390/scipharm89020015 DOI: https://doi.org/10.3390/scipharm89020015
  20. Nieves EA, Cotto MC, Márquez F. Transferosomes as Drug Delivery Systems: Design Principles, Deformability, and Translational Challenges. Pharmaceuticals. 2026;19(6):956. DOI: 10.3390/ph19060956 DOI: https://doi.org/10.3390/ph19060956
  21. Opatha, S. A. T., Titapiwatanakun, V., & Chutoprapat, R. (2020). Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery. Pharmaceutics, 12(9), 855. https://doi.org/10.3390/pharmaceutics12090855 DOI: https://doi.org/10.3390/pharmaceutics12090855
  22. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71. DOI: https://doi.org/10.1136/bmj.n71
  23. Rai, S., Pandey, V., & Rai, G. (2017). Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: The state of the art. Nano Reviews & Experiments, 8(1), 1325708. https://doi.org/10.1080/20022727.2017.1325708 DOI: https://doi.org/10.1080/20022727.2017.1325708
  24. Rajan, R., Jose, S., Mukund, V. P., & Vasudevan, D. T. (2011). Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation. Journal of advanced pharmaceutical technology & research, 2(3), 138–143. https://doi.org/10.4103/2231-4040.85524 DOI: https://doi.org/10.4103/2231-4040.85524
  25. Rajendran, A., Elumalai, V., Balasubramaniyam, S., & Elumalai, K. (2025). Transferosome Formulations as innovative carriers for transdermal drug delivery: composition, properties, and therapeutic applications. Biomedical Materials & Devices, 4(1), 105–131. https://doi.org/10.1007/s44174-024-00269-y DOI: https://doi.org/10.1007/s44174-024-00269-y
  26. Rakesh, P., Shweta, P., Kamal, S., Parul, W., & Manish, K. (2021). Transferosomes: Unique vesicular carriers for effective transdermal delivery. Journal of Applied Pharmaceutical Science. https://doi.org/10.7324/japs.2021.110501 DOI: https://doi.org/10.7324/JAPS.2021.110501
  27. Rasheed, M.S., Ansari, S.F. & Shahzadi, I.(2022). Formulation, characterization of glucosamine loaded transfersomes and in vivo evaluation using papain induced arthritis model. Sci Rep 12, 19813. https://doi.org/10.1038/s41598-022-23103-1 DOI: https://doi.org/10.1038/s41598-022-23103-1
  28. Santo, I. E., Campardelli, R., Albuquerque, E. C., De Melo, S. V., Della Porta, G., & Reverchon, E. (2014). Liposomes preparation using a supercritical fluid assisted continuous process. Chemical Engineering Journal, 249, 153–159. https://doi.org/10.1016/j.cej.2014.03.099 DOI: https://doi.org/10.1016/j.cej.2014.03.099
  29. Tapfumaneyi, P., Imran, M., Mohammed, Y., & Roberts, M. S. (2022). Recent advances and future prospective of topical and transdermal delivery systems. Frontiers in Drug Delivery, 2. https://doi.org/10.3389/fddev.2022.957732 DOI: https://doi.org/10.3389/fddev.2022.957732
  30. Wang, Y. Z., Wang, Z. X., Jiang, H. J., Ni, L. H., Ju, H., Wu, Y. C., & Li, H. J. (2025). Advances in the use of nanotechnology for treating gout. Nanomedicine (London, England), 20(4), 355–369. https://doi.org/10.1080/17435889.2025.2457315 DOI: https://doi.org/10.1080/17435889.2025.2457315