Main Article Content
Abstract
The poultry industry plays an important role in supplying animal protein and strengthening global food security, and vaccination is considered the most effective method for the control and prevention of poultry diseases. Understanding vaccine types, routes of administration, and factors affecting their effectiveness is crucial for the success of vaccination programs. The main objective of this article is to introduce the major poultry vaccines and to evaluate the existing challenges and solutions in implementing vaccination strategies. This article is based on a review of scientific literature and guidelines. The findings indicate that various vaccines, including inactivated, live attenuated, recombinant, subunit, viral vector, virus-like particle, DNA, and mRNA vaccines, are available for major poultry diseases. Multiple factors, such as improper vaccine storage and transportation, stress, immunosuppressive diseases, and incorrect vaccination schedules, contribute to vaccination failure. Therefore, the development of a national poultry vaccination policy, the provision of high-quality vaccines, and adherence to technical guidelines are essential.
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References
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- Abdul-Cader, M. S., Palomino-Tapia, V., Amarasinghe, A., Ahmed-Hassan, H., De Silva Senapathi, U., & Abdul-Careem, M. F. (2018). Hatchery vaccination against poultry viral diseases: potential mechanisms and limitations. Viral immunology, 31(1), 23-33. DOI: 10.1089/vim.2017.0050
- Acevedo-Villanueva, K. Y., Akerele, G. O., Al Hakeem, W. G., Renu, S., Shanmugasundaram, R., & Selvaraj, R. K. (2021). A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers. Vaccines, 9(9), 1041. https://doi.org/10.3390/vaccines9091041
- Aida V, Pliasas VC, Neasham PJ,North JF, McWhorter KL, Glover SR and Kyriakis CS (2021) Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines. Front. Vet. Sci. 8:654289. https:// doi: 10.3389/fvets.2021.654289
- Aqib, A.I.; Anjum, A.A.; Islam, M.A.; Murtaza, A.; Rehman, A.u. (2023). Recent Global Trends in Vaccinology, Advances and Challenges. Vaccines, 11, 520. https://doi.org/10.3390/ vaccines11030520
- Avellaneda, G., Mundt, E., Lee, C. W., Jadhao, S., & Suarez, D. L. (2010). Differentiation of infected and vaccinated animals (DIVA) using the NS1 protein of avian influenza virus. Avian diseases, 54(s1), 278-286. https://doi.org/10.1637/8644-020409-Reg.1
- Badakaya, A. S., Umar, B., Rabiu, M. A., & Danhassan, B. A. (2021). A Review of Effects of Vaccination Failures on Poultry Production in Climatic Conditions of the Sudan Savannah. Anim Health J, 2(1), 16-24. DOI: https://doi.org/10.47941/ahj.547
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- Birhane, N., & Fesseha, H. (2020). Vaccine failure in poultry production and its control methods: A review. Biomed. J. Sci. Tech. Res, 29(4), 22588-22596. DOI: 10.26717/BJSTR.2020.29.004827
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- Chapman, H. D., & Jeffers, T. K. (2014). Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production. International Journal for Parasitology: Drugs and Drug Resistance, 4(3), 214-217. http://dx.doi.org/10.1016/j.ijpddr.2014.10.002
- Fan, X., Hu, Y., Zhang, G., & Wang, M. (2015). Veterinary influenza vaccines against avian influenza in China. Future Virology, 10(5), 585-595. https://doi.org/10.2217/fvl.15.23
- Igbokwe, I. O., Maduka, C. V., Igbokwe, N. A., Ogbaji, S. J., Onah, C. C., & Atsanda, N. N. (2020). Adoption and failure rates of vaccinations for disease prevention in chicken farms in Jos, Nigeria. Tropical Animal Health and Production, 52(6), 3113-3121. https://doi.org/10.1007/s11250-020-02335-1
- Islam, M. S., & Rahman, M. T. (2023). A Comprehensive review on bacterial vaccines combating antimicrobial resistance in poultry. Vaccines, 11(3), 616. https://doi.org/10.3390/vaccines11030616
- Jacob, J. (2013). Poultry Vaccines for Use on Organic Farms, eOrganic article compliance with National Organic Program regulations by members of the eOrganic community, [Online] Accessed on: 18 Dec 2025; retrieved from: Link
- Kathiravan.S., Valavan.P., Madhanraj.N., Alimudeen.S. and Hariharan.R (2023). Vaccination Failure in Poultry Production New Era Agricultural Magazine, 2(1): 19-30, Retreived from: Link
- Kozak, M., Hu, J. (2024). DNA Vaccines: Their Formulations, Engineering and Delivery. Vaccines, 12, 71. https://doi.org/10.3390/vaccines12010071
- Landman, W.J.M. (2012) The downside of broiler vaccination, Veterinary Quarterly, 32:3-4, 121-122,
- https://: doi10.1080/01652176.2012.729657
- León-Montoya, H., & Angulo, C. (2025). Cutting-edge progress in the protective efficacy of nanovaccines against poultry diseases. World’s Poultry Science Journal, 81(2), 403–425. https://doi.org/10.1080/00439339.2025.2461723
- Liu F, Wu X, Li L, Ge S, Liu Z, Wang Z. (2013). Virus-like particles: Promising platforms with characteristics of DIVA for veterinary vaccine design. Comparative Immunology, Microbiology and Infectious Diseases. Jul 1;36(4):343-52. https://doi: 10.1016/j.cimid.2013.02.002.
- Mateen, A.; Arslan, M.; Ali, R. F.; Usman, M.; Elahi, U. (2025). Beyond Antibiotics: A review of sustainable strategies and emerging alternatives for poultry health management in modern farming. Insights Anim. Sci 1-22, (1)2 https://doi.org/10.69917/ias.02.01-01
- Mayers J., Mansfield, K.L., Brown I.H. (2017). The role of vaccination in risk mitigation and control of Newcastle disease in poultry. Vaccine, https://doi.org/10.1016/j.vaccine.2017.09.008
- Metwally, S., Viljoen, G., & El Idrissi, A. (2021). VeterinaryVaccines: Principlesand Applications. The Food and Agriculture Organization of the United Nations and John Wiley & Sons Limited, Retrieved from: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119506287
- Otiang E, Thumbi SM, Campbell ZA, Njagi LW, Nyaga PN, Palmer GH (2021) Impact of routine Newcastle disease vaccination on chicken flock size in smallholder farms in western Kenya. PLoS ONE 16(3): e0248596. https://doi.org/10.1371/journal.pone.0248596
- Rabie, N. S., & Amin Girh, Z. M. (2020). Bacterial vaccines in poultry. Bulletin of the National Research Centre, 44(1), 15. https://doi.org/10.1186/s42269-019-0260-1
- Ravikumar, R.; Chan, J.; Prabakaran, M. (2022). Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy. Viruses, 14, 1195. https://doi.org/10.3390/v14061195
- Salih, A., Mohammed, L., & Bara, A. (2025). Molecular Evidence of Marek’s Disease Virus Evolution from Commercial Poultry Flocks in Iraq. Assiut Veterinary Medical Journal, 71(187), 655-669https://foi10.21608/avmj.2025.353190.1560
- Sana, S.S.; Atuahene, D.; Nagy, V.; Shaikh, A.M.; Knop, R. (2025). The Rising Threat of Antibiotic Resistance in Poultry: Veterinary and One Health Perspectives. Vet. Sci., 12, 1059. https://doi.org/10.3390/vetsci12111059
- Sharif, A., & Ahmad, T. (2018). Preventing vaccine failure in poultry flocks. In Immunization-Vaccine Adjuvant Delivery System and Strategies. IntechOpen. http://dx.doi.org/10.5772/intechopen.79330
- Stewart-Brown B. (2024). Vaccination Programs for Poultry, MSD Veterinary Manual [Online], Accessed on: 18 Dec 2025; Retrieved from: Link
- Swayne, D. E. (2012). Impact of vaccines and vaccination on global control of avian influenza. Avian diseases, 56(4s1), 818-828. https://doi.org/10.1637/10183-041012-Review.1
- Toka, T., & Geinoro, T. (2023). Vaccine failure and its control methods in poultry production. British Journal of Poultry Sciences, 12(2), 63-73. https://: 10.5829/idosi.bjps.2023.63.73
- Tsion B, Fanose T. (2023). Review on Discriminatory Tests of Immune Reacton due to Infecton and Vaccinaton (DIVA Test). Austn J Vet Sci & Anim Husb.; 10(3): 1120, Link
- Vijay, D., Dhaka, P., J.S Bedi and R.S Aulakh (2019).Veterinary Vaccines: A Silver Bullet for Animal Health in Low-and-Middle Income Countries, International Veterinary Vaccinology Network, School of Public Health and Zoonoses, Guru Angad Dev Veterinary and Animal Sciences University, India [Online], Accesses 20 Oct 2025. Available at: Link
- Wang, H., Tian, J., Zhao, J., Zhao, Y., Yang, H., Zhang, G. (2024). Current Status of Poultry Recombinant Virus Vector Vaccine Development. Vaccines, 12, 630. https://doi.org/10.3390/vaccines12060630
References
Abdallah, N., Tekelioğlu, B. K., Kurşun, K., Baylan, M., & Elçi, Ümit (2023). Vaccination and Poultry (chicken) Production. Journal of Agriculture, Food, Environment and Animal Sciences, 4(1), 119-136. Retrieved from Link
Abdul-Cader, M. S., Palomino-Tapia, V., Amarasinghe, A., Ahmed-Hassan, H., De Silva Senapathi, U., & Abdul-Careem, M. F. (2018). Hatchery vaccination against poultry viral diseases: potential mechanisms and limitations. Viral immunology, 31(1), 23-33. DOI: 10.1089/vim.2017.0050
Acevedo-Villanueva, K. Y., Akerele, G. O., Al Hakeem, W. G., Renu, S., Shanmugasundaram, R., & Selvaraj, R. K. (2021). A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers. Vaccines, 9(9), 1041. https://doi.org/10.3390/vaccines9091041
Aida V, Pliasas VC, Neasham PJ,North JF, McWhorter KL, Glover SR and Kyriakis CS (2021) Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines. Front. Vet. Sci. 8:654289. https:// doi: 10.3389/fvets.2021.654289
Aqib, A.I.; Anjum, A.A.; Islam, M.A.; Murtaza, A.; Rehman, A.u. (2023). Recent Global Trends in Vaccinology, Advances and Challenges. Vaccines, 11, 520. https://doi.org/10.3390/ vaccines11030520
Avellaneda, G., Mundt, E., Lee, C. W., Jadhao, S., & Suarez, D. L. (2010). Differentiation of infected and vaccinated animals (DIVA) using the NS1 protein of avian influenza virus. Avian diseases, 54(s1), 278-286. https://doi.org/10.1637/8644-020409-Reg.1
Badakaya, A. S., Umar, B., Rabiu, M. A., & Danhassan, B. A. (2021). A Review of Effects of Vaccination Failures on Poultry Production in Climatic Conditions of the Sudan Savannah. Anim Health J, 2(1), 16-24. DOI: https://doi.org/10.47941/ahj.547
Bilal, M., Samoon, F. A., Fahad, M., Shafiq, M. S., Iftikhar, M. A., Ahmad, Y., & Abdullah, O. M. (2025). Strategies for Improving Immunity and Production in Broilers: Impact of Vaccination on Poultry Health. Haya Saudi J. Life Sci., 10, 94-103. DOI: https://doi.org/10.36348/sjls.2025.v10i03.006
Birhane, N., & Fesseha, H. (2020). Vaccine failure in poultry production and its control methods: A review. Biomed. J. Sci. Tech. Res, 29(4), 22588-22596. DOI: 10.26717/BJSTR.2020.29.004827
Bodman-Harris O, Rollier CS, Iqbal M. (2024). Approaches to Enhance the Potency of Vaccines in Chickens. Vaccines (Basel); 12(12):1337. https://10.3390/vaccines12121337. PMID: 39771998; PMCID: PMC11680195.
Chapman, H. D., & Jeffers, T. K. (2014). Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production. International Journal for Parasitology: Drugs and Drug Resistance, 4(3), 214-217. http://dx.doi.org/10.1016/j.ijpddr.2014.10.002
Fan, X., Hu, Y., Zhang, G., & Wang, M. (2015). Veterinary influenza vaccines against avian influenza in China. Future Virology, 10(5), 585-595. https://doi.org/10.2217/fvl.15.23
Igbokwe, I. O., Maduka, C. V., Igbokwe, N. A., Ogbaji, S. J., Onah, C. C., & Atsanda, N. N. (2020). Adoption and failure rates of vaccinations for disease prevention in chicken farms in Jos, Nigeria. Tropical Animal Health and Production, 52(6), 3113-3121. https://doi.org/10.1007/s11250-020-02335-1
Islam, M. S., & Rahman, M. T. (2023). A Comprehensive review on bacterial vaccines combating antimicrobial resistance in poultry. Vaccines, 11(3), 616. https://doi.org/10.3390/vaccines11030616
Jacob, J. (2013). Poultry Vaccines for Use on Organic Farms, eOrganic article compliance with National Organic Program regulations by members of the eOrganic community, [Online] Accessed on: 18 Dec 2025; retrieved from: Link
Kathiravan.S., Valavan.P., Madhanraj.N., Alimudeen.S. and Hariharan.R (2023). Vaccination Failure in Poultry Production New Era Agricultural Magazine, 2(1): 19-30, Retreived from: Link
Kozak, M., Hu, J. (2024). DNA Vaccines: Their Formulations, Engineering and Delivery. Vaccines, 12, 71. https://doi.org/10.3390/vaccines12010071
Landman, W.J.M. (2012) The downside of broiler vaccination, Veterinary Quarterly, 32:3-4, 121-122,
https://: doi10.1080/01652176.2012.729657
León-Montoya, H., & Angulo, C. (2025). Cutting-edge progress in the protective efficacy of nanovaccines against poultry diseases. World’s Poultry Science Journal, 81(2), 403–425. https://doi.org/10.1080/00439339.2025.2461723
Liu F, Wu X, Li L, Ge S, Liu Z, Wang Z. (2013). Virus-like particles: Promising platforms with characteristics of DIVA for veterinary vaccine design. Comparative Immunology, Microbiology and Infectious Diseases. Jul 1;36(4):343-52. https://doi: 10.1016/j.cimid.2013.02.002.
Mateen, A.; Arslan, M.; Ali, R. F.; Usman, M.; Elahi, U. (2025). Beyond Antibiotics: A review of sustainable strategies and emerging alternatives for poultry health management in modern farming. Insights Anim. Sci 1-22, (1)2 https://doi.org/10.69917/ias.02.01-01
Mayers J., Mansfield, K.L., Brown I.H. (2017). The role of vaccination in risk mitigation and control of Newcastle disease in poultry. Vaccine, https://doi.org/10.1016/j.vaccine.2017.09.008
Metwally, S., Viljoen, G., & El Idrissi, A. (2021). VeterinaryVaccines: Principlesand Applications. The Food and Agriculture Organization of the United Nations and John Wiley & Sons Limited, Retrieved from: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119506287
Otiang E, Thumbi SM, Campbell ZA, Njagi LW, Nyaga PN, Palmer GH (2021) Impact of routine Newcastle disease vaccination on chicken flock size in smallholder farms in western Kenya. PLoS ONE 16(3): e0248596. https://doi.org/10.1371/journal.pone.0248596
Rabie, N. S., & Amin Girh, Z. M. (2020). Bacterial vaccines in poultry. Bulletin of the National Research Centre, 44(1), 15. https://doi.org/10.1186/s42269-019-0260-1
Ravikumar, R.; Chan, J.; Prabakaran, M. (2022). Vaccines against Major Poultry Viral Diseases: Strategies to Improve the Breadth and Protective Efficacy. Viruses, 14, 1195. https://doi.org/10.3390/v14061195
Salih, A., Mohammed, L., & Bara, A. (2025). Molecular Evidence of Marek’s Disease Virus Evolution from Commercial Poultry Flocks in Iraq. Assiut Veterinary Medical Journal, 71(187), 655-669https://foi10.21608/avmj.2025.353190.1560
Sana, S.S.; Atuahene, D.; Nagy, V.; Shaikh, A.M.; Knop, R. (2025). The Rising Threat of Antibiotic Resistance in Poultry: Veterinary and One Health Perspectives. Vet. Sci., 12, 1059. https://doi.org/10.3390/vetsci12111059
Sharif, A., & Ahmad, T. (2018). Preventing vaccine failure in poultry flocks. In Immunization-Vaccine Adjuvant Delivery System and Strategies. IntechOpen. http://dx.doi.org/10.5772/intechopen.79330
Stewart-Brown B. (2024). Vaccination Programs for Poultry, MSD Veterinary Manual [Online], Accessed on: 18 Dec 2025; Retrieved from: Link
Swayne, D. E. (2012). Impact of vaccines and vaccination on global control of avian influenza. Avian diseases, 56(4s1), 818-828. https://doi.org/10.1637/10183-041012-Review.1
Toka, T., & Geinoro, T. (2023). Vaccine failure and its control methods in poultry production. British Journal of Poultry Sciences, 12(2), 63-73. https://: 10.5829/idosi.bjps.2023.63.73
Tsion B, Fanose T. (2023). Review on Discriminatory Tests of Immune Reacton due to Infecton and Vaccinaton (DIVA Test). Austn J Vet Sci & Anim Husb.; 10(3): 1120, Link
Vijay, D., Dhaka, P., J.S Bedi and R.S Aulakh (2019).Veterinary Vaccines: A Silver Bullet for Animal Health in Low-and-Middle Income Countries, International Veterinary Vaccinology Network, School of Public Health and Zoonoses, Guru Angad Dev Veterinary and Animal Sciences University, India [Online], Accesses 20 Oct 2025. Available at: Link
Wang, H., Tian, J., Zhao, J., Zhao, Y., Yang, H., Zhang, G. (2024). Current Status of Poultry Recombinant Virus Vector Vaccine Development. Vaccines, 12, 630. https://doi.org/10.3390/vaccines12060630