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Abstract

The use of medicinal plants and herbal remedies to address pregnancy-related issues is widespread among expectant mothers. However, certain plants contain bioactive compounds with teratogenic properties, which can lead to adverse outcomes such as fetal death, congenital malformations, growth retardation, and functional impairments in the fetus or newborn. These adverse effects are attributed to specific toxic constituents with teratogenic potential. This narrative review article introduces the poisonous plants with teratogenic effects and the phytochemicals responsible for their teratogenicity. This study highlights that several medicinal plants commonly employed during pregnancy possess teratogenic effects, primarily due to active compounds such as alkaloids, glycosides, terpenoids, and flavonoids. Although the teratogenicity of these plants has been demonstrated predominantly in experimental models, and in some instances further investigation is necessary for conclusive evidence, it is nevertheless advisable to avoid the use of these plants during pregnancy.

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Alkaloids Cyanogenic Glycosides Medicinal Plants Pregnancy Teratogenic Effects

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Ayoubi, R. (2025). A Review of Poisonous Plants with Teratogenic Effects. Journal of Natural Sciences – Kabul University, 8(2), 35–65. https://doi.org/10.62810/jns.v8i2.387
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References

  1. Adane, F., Seyoum, G., Alamneh, Y. M., Abie, W., Desta, M., & Sisay, B. (2020). Herbal medicine use and predictors among pregnant women attending antenatal care in Ethiopia: a systematic review and meta-analysis. BMC Pregnancy and Childbirth volume, 20, 157. https://doi.org/10.1186/s12884-020-2856-8 DOI: https://doi.org/10.1186/s12884-020-2856-8
  2. Ahmed, S. M., Nordeng, H., Sundby, J., Aragaw, Y. A., & de Boer, H. J. (2018). The use of medicinal plants by pregnant women in Africa: A systematic review. J Ethnopharmacol, 224, 297-313. https://doi:10.1016/j.jep.2018.05.032. DOI: https://doi.org/10.1016/j.jep.2018.05.032
  3. Alafiatayo, A. A., Lai, K.-S., Syahida, A., Mahmood, M., & Shaharuddin, N. A. (2019). Phytochemical Evaluation, Embryotoxicity, and Teratogenic Effects of Curcuma longa Extract on Zebrafish (Danio rerio). Evid Based Complement Alternat Med, 2019, 3807207. https://doi:10.1155/2019/3807207. DOI: https://doi.org/10.1155/2019/3807207
  4. Amorim, M. H., da Costa, R. M., Lopes, C., & Bastos, M. M. (2013). Sesquiterpene lactones: adverse health effects and toxicity mechanisms. Crit Rev Toxicol, 43(7), 559-79. https://doi:10.3109/10408444.2013.813905 DOI: https://doi.org/10.3109/10408444.2013.813905
  5. Abramovici, A. (1972). The Teratogenic Effect of Cosmetic Constituents on the Chick Embryo. In M. A. Klingerg, A. Abramovici, & J. Chemke (Eds.), Drugs and Fetal Development. Advances in Experimental Medicine and Biology (Vol. 27, pp. 161–174). Springer. https://doi.org/10.1007/978-1-4684-3219-0_13 DOI: https://doi.org/10.1007/978-1-4684-3219-0_13
  6. Artimani, T., Shabanian, S., Heidari-Soureshjan, S., Asadi-Samani, M., & Luther, T. (2017). A REVIEW OF IRANIAN MEDICINAL PLANTS WITH TERATOGENIC AND ABORTION-INDUCING SIDE EFFECTS. International Journal of Pharmaceutical Sciences and Research, 8(6), 2372-2377. https:// doi:10.13040/IJPSR.0975-8232.8(6).2372-77 DOI: https://doi.org/10.13040/IJPSR.0975-8232.8(6).2372-77
  7. Balarastaghi,, S., Delirrad, M., Jafari, A., Majidi, M., Sadeghi, M., Zare-Zardini, H., . . . Ghorani-Azam, A. (2022). Potential benefits versus hazards of herbal therapy during pregnancy; a systematic review of available literature. Phtother Res, 36(2), 824-841. https://doi.org/10.1002/ptr.7363 DOI: https://doi.org/10.1002/ptr.7363
  8. Başaran, N., Paslı, D., & A, B. A. (2022). Unpredictable adverse effects of herbal products. Food and Chemical Toxicology, 159, 112762. https://doi.org/10.1016/j.fct.2021.112762 DOI: https://doi.org/10.1016/j.fct.2021.112762
  9. Bernstein, N., Akram, M., Yaniv-Bachrach, Z., & Daniya, M. (2021). Is it safe to consume traditional medicinal plants during pregnancy? Phytotherapy Research, 35(4), 1908-1924. https://doi.org/10.1002/ptr.6935 DOI: https://doi.org/10.1002/ptr.6935
  10. Binns, W., Shupe, J. L., Keeler, R. F., & James, L. F. (1965). Chronologic evaluation of teratogenicity in sheep fed Veratrum californicum. J Am Vet Med Assoc, 147(8), 839-42. Retrieved from Link
  11. Breeta, R. E., Jesubatham, P. D., Grace, V. B., Viswanathan, S., & Srividya, S. (2018). Non-toxic and non teratogenic extract of Thuja orientalis L. inhibited angiogenesis in zebra fish and suppressed the growth of human lung cancer cell line. Biomed Pharmacother, 106, 699-706. https://doi:10.1016/j.biopha.2018.07.010 DOI: https://doi.org/10.1016/j.biopha.2018.07.010
  12. Bruno, L. O., Simoes, R. S., Simoes, M. d., Girão, M. J., & Grundmann, O. (2018). Pregnancy and herbal medicines: An unnecessary risk for women's health-A narrative review. Phytother Res., 32(5), 796-810. https:// doi:10.1002/ptr.6020 DOI: https://doi.org/10.1002/ptr.6020
  13. Chamorro-Cevallos, G., Mojica-Villegas, M. A., García-Martínez, Y., Pérez-Gutiérrez, S., & et al. (2022). A Complete Review of Mexican Plants with Teratogenic Effects. Plants, 11(13), 1675. https://doi.org/10.3390/plants11131675 DOI: https://doi.org/10.3390/plants11131675
  14. Chen, L., Xu, M., Gong, Z., Zonyane, S., Xu, S., & Makunga, N. P. (2018). Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. detected using a zebrafish Tuebingen embryo model. BMC Complementary and Alternative Medicine, 18, 273. https://doi.org/10.1186/s12906-018-2303-9 DOI: https://doi.org/10.1186/s12906-018-2303-9
  15. Conover, E., & Buehler, B. A. (2004). Use of herbal agents by breastfeeding women may affect infants. Pediatr Ann, 33(4), 235-40. https:// doi:10.3928/0090-4481-20040401-09. DOI: https://doi.org/10.3928/0090-4481-20040401-09
  16. Costa-Lotufo, L. V., Cunha, G. M., Farias, P. A., Viana,, G. S., Cunha, K. M., & et al. (2002). The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin. Toxicon, 40(8), 1231-234. https://doi:10.1016/s0041-0101(02)00128-9. DOI: https://doi.org/10.1016/S0041-0101(02)00128-9
  17. da Silva Costa, K. C., Bezerra, S. B., Norte, C. M., Nunes, L. M., & de Olinda, T. M. (2012). *Correspondence: T. M. Olinda. Departamento de Farmácia. Rua Cap. Francis-. Brazilian Journal of Pharmaceutical Sciences, 48(3), 427-433. Retrieved from Link DOI: https://doi.org/10.1590/S1984-82502012000300009
  18. de Araújo, C. R., Santiago, F. G., Peixoto, M. I., de Oliveira, J. D., & Coutinho, M. d. (2016). Use of Medicinal Plants with Teratogenic and Abortive Effects by Pregnant Women in a City in Northeastern Brazil. Rev Bras Ginecol Obstet, 38(3), 127-31. https://doi:10.1055/s-0036-1580714 DOI: https://doi.org/10.1055/s-0036-1580714
  19. de Sá Hyacienth, B. M., Sánchez-Ortiz, B. L., Picanço, K. R., Pereira, A. C., de Sá Hyacienth, D. C., & et al. . (2020). Endopleura uchi (Huber) Cuatrec.: A medicinal plant for gynecological treatments – A reproductive toxicity assessment in zebrafish (Danio rerio). Journal of Ethnopharmacology, 250, 112457. https://doi.org/10.1016/j.jep.2019.112457 DOI: https://doi.org/10.1016/j.jep.2019.112457
  20. de Villarreal, L. M., Velazco-Campos, R., López, A. P., & Alanís, R. G. (1990). Effects of toxin T-544 from the Karwinskia humboldtiana (buckthorn) plant upon mouse embryos explanted at 11 days. Toxicon, 28(4), 449-52. https://doi:10.1016/0041-0101(90)90084-k. DOI: https://doi.org/10.1016/0041-0101(90)90084-K
  21. Ekor, M. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol, 4, 177. https://doi:10.3389/fphar.2013.00177. DOI: https://doi.org/10.3389/fphar.2013.00177
  22. Gardner, D., Riet-Correa, F., Lemos, D., Welch, K., Pfister, J., & Panter, K. (2014). Teratogenic Effects of Mimosa tenuiflora in a Rat Model and Possible Role of N-Methyl- and N,N-Dimethyltryptamine. Journal of Agricultural and Food Chemistry, 62(30), 7398–7401. https://doi.org/10.1021/jf5005176 DOI: https://doi.org/10.1021/jf5005176
  23. Gordeĭchuk, T. N., Chebotar, N. A., Konopistseva, L. A., & Puchkov, V. F. (1993). The prevention of congenital developmental anomalies in rats. Ontogenez, 24(1), 48-55. Retrieved from https://pubmed.ncbi.nlm.nih.gov/8474760/
  24. Jafarzadeh, L., Seifi, N., Shahinfard, N., Sedighi, M., Kheiri, S., & et al. (2015). Antioxidant Activity and Teratogenicity Evaluation of Lawsonia Inermis in BALB/c Mice. J Clin Diagn Res, 9(5), FF01-4. https://doi:10.7860/JCDR/2015/12290.5911 DOI: https://doi.org/10.7860/JCDR/2015/12290.5911
  25. James, L. F. (1977). Plant-induced congenital malformations in animals. World Rev Nutr Diet, 26, 208-24. https:// doi:10.1159/000428539. DOI: https://doi.org/10.1159/000428539
  26. Jedlinszki, N., Balázs, B., Csányi, E., & Csupor, D. (2017). Penetration of lycopsamine from a comfrey ointment through human epidermis. Regul Toxicol Pharmacol, 83, 1-4. https://doi:10.1016/j.yrtph.2016.11.015 DOI: https://doi.org/10.1016/j.yrtph.2016.11.015
  27. Karol, M. O., Conner, C. S., Watanabe,, A. S., & Murphrey, K. J. (1980). Podophyllum: suspected teratogenicity from topical application. Clin Toxicol, 16(3), 283-6. https://doi:10.3109/15563658008989950. DOI: https://doi.org/10.3109/15563658008989950
  28. Keeler, R. F. (1970). Teratogenic compounds in Veratrum californicum (Durand). IX. Structure-activity relation. Teratology, 3(2), 169-173. https://doi:10.1002/tera.1420030209 DOI: https://doi.org/10.1002/tera.1420030209
  29. Keeler, R. F. (1970). Teratogenic compounds of Veratrum californicum (Durand). X. Cyclopia in rabbits produced by cyclopamine. Teratology, 3(2), 175-180. https://doi.org/10.1002/tera.1420030210 DOI: https://doi.org/10.1002/tera.1420030210
  30. Keeler, R. F. (1971). Teratogenic compounds of Veratrum californicum (Durand). 13. Structure of muldamine. Steroids, 18(6), 741-752. https://doi.org/10.1016/0039-128X(71)90033-X DOI: https://doi.org/10.1016/0039-128X(71)90033-X
  31. Keeler, R. F. (1971). Teratogenic compounds of Veratrum californicum (Durand). XI. Gestational chronology and compound specificity in rabbits. Proc Soc Exp Biol Med, 136(4), 1174-9. https://doi:10.3181/00379727-136-35453 DOI: https://doi.org/10.3181/00379727-136-35453
  32. Keeler, R. F. (1973). Teratogenic Compounds of Veratrum californicum (Durand). XIV. Limb Deformities Produced by Cyclopamine. Proceedings of the Society for Experimental Biology and Medicine, 142(4), 1287-1291. https://doi:10.3181/00379727-142-37225 DOI: https://doi.org/10.3181/00379727-142-37225
  33. Keeler, R. F. (1984). Teratogens in Plants. Journal of Animal Science, 58(4), 1029–1039. https://doi.org/10.2527/jas1984.5841029x DOI: https://doi.org/10.2527/jas1984.5841029x
  34. Keeler, R. F., & Binns, W. (1966). Possible Teratogenic Effects of Veratramine. Proceedings of the Society for Experimental Biology and Medicine, 123(3), 921-923. https://doi:10.3181/00379727-123-31639 DOI: https://doi.org/10.3181/00379727-123-31639
  35. Keeler, R. F., & Binns, W. (1966). Teratogenic compounds of Veratrum californicum (Durand). I. Preparation and characterization of fractions and alkaloids for biologic testing. Can J Biochem, 44(6), 819-28. https://doi:10.1139/o66-100. DOI: https://doi.org/10.1139/o66-100
  36. Keeler, R. F., & Binns, W. (1966). TERATOGENIC COMPOUNDS OF VERATRUM CALIFORNICUM (DURAND): II. PRODUCTION OF OVINE FETAL CYCLOPIA BY FRACTIONS AND ALKALOID PREPARATIONS. Canadian Journal of Biochemistry, 44(6), 829-838. https://doi.org/10.1139/o66-101 DOI: https://doi.org/10.1139/o66-101
  37. Keeler, R. F., & Binns, W. (1968). Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology, 1(1), 5-10. https://doi.org/10.1002/tera.1420010103 DOI: https://doi.org/10.1002/tera.1420010103
  38. Keeler, R. J., & Binns, W. (1967). Teratogenic compounds of Veratrum californicum (Durand). 3. Malformations of the veratramine-induced type from ingestion of plant or roots. Proc Soc Exp Biol Med, 126(2), 452-4. https://doi:10.3181/00379727-126-32474. DOI: https://doi.org/10.3181/00379727-126-32474
  39. Kennelly, E. J., Flynn, T. J., Mazzola, E. P., Roach, J. A., McCloud, T. G., Danford, D. E., & Betz, J. M. (1999). Detecting Potential Teratogenic Alkaloids from Blue Cohosh Rhizomes Using an in Vitro Rat Embryo Culture. Journal of Natural Products, 62(10), 1385–1389. https://doi.org/10.1021/np9901581 DOI: https://doi.org/10.1021/np9901581
  40. Khalki, L., M'hamed, S. B., Bennis, M., Chait, A., & Sokar, Z. (2010). Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice. J Ethnopharmacol, 131(2), 321-5. https://doi:10.1016/j.jep.2010.06.033 DOI: https://doi.org/10.1016/j.jep.2010.06.033
  41. Khan, M. F., Abutaha, N., Nasr, F. A., Alqahtani, A. S., Noman, O. M., & Wadaan, M. A. (2019). Bitter gourd (Momordica charantia) possess developmental toxicity as revealed by screening the seeds and fruit extracts in zebrafish embryos. BMC Complementary and Alternative Medicine volume, 19, 184 . https://doi.org/10.1186/s12906-019-2599-0 DOI: https://doi.org/10.1186/s12906-019-2599-0
  42. Kim, S. H., Kim, Y. H., Han, S. S., & Roh, J. K. (1993). Teratogenicity study of Scutellariae Radix in rats. Reprod Toxicol, 7(1), 73-9. doi:10.1016/0890-6238(93)90012-v. DOI: https://doi.org/10.1016/0890-6238(93)90012-V
  43. Kristanc, L., & Kreft, S. (2016). European medicinal and edible plants associated with subacute and chronic toxicity part I: Plants with carcinogenic, teratogenic and endocrine-disrupting effects. Food Chem Toxicol, 92, 150-64. https://doi:10.1016/j.fct.2016.04.007. DOI: https://doi.org/10.1016/j.fct.2016.04.007
  44. Leung, K.-Y., Lee, Y.-P., Chan, H.-Y., Lee, C.-P., & Tang, M. H.-Y. (2002). Are herbal medicinal products less teratogenic than Western pharmaceutical products. Acta Pharmacol Sin, 23(12), 1169-72. Retrieved from Link
  45. Lunagómez, L. S., Santiago-Roque, I., Gheno-Heredia, Y. A., Corona-Morales, A. A., & Bolado-García, V. E. (2020). Teratogenic effects of Bocconia frutescens L. J Dev Orig Health Dis, 7, 1-4. https://doi:10.1017/S2040174419000461. DOI: https://doi.org/10.1017/S2040174419000461
  46. Macías-Peacok, B., Pérez-Jackson, L., Suárez-Crespo, M. F., Fong-Domínguez, C. O., & Pupo-Perera, E. (2009). Use of medicinal plants during pregnancy. Rev Med Inst Mex Seguro Soc, 47(3), 331-4. Retrieved from link
  47. Majeed, I., Rizwan, K., Ashar, A., Rasheed, T., Amarowicz, R., & et al. (2021). A Comprehensive Review of the Ethnotraditional Uses and Biological and Pharmacological Potential of the Genus Mimosa. Int. J. Mol. Sci., 22(14), 7463. doi:https://doi.org/10.3390/ijms22147463 DOI: https://doi.org/10.3390/ijms22147463
  48. Martins, M. L., Martins, H. M., & Bernardo, F. (2001). Fumonisins B1 and B2 in black tea and medicinal plants. J Food Prot, 64(8), 1268-70. https://doi:10.4315/0362-028x-64.8.1268. DOI: https://doi.org/10.4315/0362-028X-64.8.1268
  49. Nagaoka, L. T., Jorge, B. C., Stein, J., Manoel, B. d., Valente, L. C., de Toledo, L. L., & et al. (2023). Maternal-fetal safety evaluation of an aqueous extract of Casearia sylvestris leaves in rats. Birth Defects Res, 115(20), 1899-1911. https://doi:10.1002/bdr2.2257. DOI: https://doi.org/10.1002/bdr2.2257
  50. Nieoczym, D., Banono, N. S., Stępnik, K., Kaczor, A. A., Szybkowski, P., Esguerra, C. V., . . . Gawel, K. (2023). In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice. Int. J. Mol. Sci., 24(16), 12949. https://doi.org/10.3390/ijms241612949 DOI: https://doi.org/10.3390/ijms241612949
  51. Omurtag, G. Z., & Yazicioğlu, D. (2004). Determination of fumonisins B1 and B2 in herbal tea and medicinal plants in Turkey by high-performance liquid chromatography. J Food Prot, 67(8), 1782-6. https://doi:10.4315/0362-028x-67.8.1782. DOI: https://doi.org/10.4315/0362-028X-67.8.1782
  52. Ortiz, H. C., das Neves, S. C., Kassuya, C. A., Coelho, H. R., Martins, A. C., Vilela, M. L., & et al. (2023). The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential. BMC Complementary Medicine and Therapies, 23, 145. https://doi.org/10.1186/s12906-023-03953-6 DOI: https://doi.org/10.1186/s12906-023-03953-6
  53. Pearn, J. H. (1967). Studies on a site-specific cleft palate teratogen. The toxic extract from Indigofera spicata Forssk. Br J Exp Pathol, 48(6), 620–626. Retrieved from Link
  54. Pósfai, É., Bánhidy, F., & Czeizel, A. E. (2013). Teratogenic effect of hydroxyethylrutoside, a flavonoid derivate drug – a population-based case–control study. The Journal of Maternal-Fetal & Neonatal Medicine, 11, 1093-1098. https://doi.org/10.3109/14767058.2013.850485 DOI: https://doi.org/10.3109/14767058.2013.850485
  55. Prakash, A. S., Pereira, T. N., Reilly, P. E., & Seawright, A. A. (1999). Pyrrolizidine alkaloids in human diet. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 443(102), 53-67. https://doi.org/10.1016/S1383-5742(99)00010-1 DOI: https://doi.org/10.1016/S1383-5742(99)00010-1
  56. Rahimi, R., & Ardekani, M. R. (2013). Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy. Chin. J. Integr. Med, 19, 73–79. https://doi.org/10.1007/s11655-013-1327-0 DOI: https://doi.org/10.1007/s11655-013-1327-0
  57. Reece, A. S., & Hulse, G. K. (2019). Cannabis Teratology Explains Current Patterns of Coloradan Congenital Defects: The Contribution of Increased Cannabinoid Exposure to Rising Teratological Trends. Clin Pediatr (Phila), 58(10), 1085-1123. https://doi:10.1177/0009922819861281 DOI: https://doi.org/10.1177/0009922819861281
  58. Reiners, J. J., & Clift, R. (1999). Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor. Carcinogenesis, 20( 8), 1561–1566. https://doi.org/10.1093/carcin/20.8.1561 DOI: https://doi.org/10.1093/carcin/20.8.1561
  59. Rezaei, S., Ahmadi, S., Mohamadi-Bolbanabad, A., & Khanijahani, A. (2020). Exploring socioeconomic inequalities in the use of medicinal herbs among Iranian households: evidence from a national cross-sectional survey. BMC Complementary Medicine and Therapies, 20, 336. https://doi.org/10.1186/s12906-020-03131-y DOI: https://doi.org/10.1186/s12906-020-03131-y
  60. Roeder, E., & Wiedenfeld, H. (2013). Plants containing pyrrolizidine alkaloids used in the traditional Indian medicine--including ayurveda. Pharmazie, 68(2), 83-92. Retrieved from . Link
  61. Rousseaux, C. G., & Schachter, H. (2003). Regulatory issues concerning the safety, efficacy and quality of herbal remedies. Birth Defects Res B Dev Reprod Toxicol, 68(6), 505-10. https://doi:10.1002/bdrb.10053 DOI: https://doi.org/10.1002/bdrb.10053
  62. Schep, L. J., Schmierer, D. M., & Fountain, J. S. (2006). Veratrum Poisoning. Toxicol Rev, 25, 73–78. https://doi.org/10.2165/00139709-200625020-00001 DOI: https://doi.org/10.2165/00139709-200625020-00001
  63. Seukep, A. J., Noumedem, J. A., Djeussi, D. E., & Kuete, V. (2014). Genotoxicity and Teratogenicity of African Medicinal Plants. In V. Kuete (Ed.), Toxicological Survey of African Medicinal Plants (pp. 235-275). Elsevier. https://doi.org/10.1016/B978-0-12-800018-2.00009-1 DOI: https://doi.org/10.1016/B978-0-12-800018-2.00009-1
  64. Sewram, V., Shephard, G. S., van der Merwe, L., & Jacobs, T. V. (2006). Mycotoxin Contamination of Dietary and Medicinal Wild Plants in the Eastern Cape Province of South Africa. Journal of Agricultural and Food Chemistry, 54(15), 5688–5693. https://doi.org/10.1021/jf060483b DOI: https://doi.org/10.1021/jf060483b
  65. Shlosberg, A., & Egyed, M. N. (1983). Examples of Poisonous Plants in Israel of Importance to Animals and Man. In C. M. Chambers, P. L. Chambers, & S. Gitter (Eds.), Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals (Vol. 6). Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-642-69083-9_34 DOI: https://doi.org/10.1007/978-3-642-69083-9_34
  66. Singulani, J. L., Pedroso, R. S., Ribeiro, A. B., Nicolella, H. D., Karoline S Freitas, Damasceno, J. L., & et al. (2018). Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish. Future Microbiol, 13, 1637-1646. https://doi:10.2217/fmb-2018-0200. DOI: https://doi.org/10.2217/fmb-2018-0200
  67. Souza Formigoni, M. L., Lodder, H. M., Gianotti Filho, O., Ferreira, T. M., & Carlini, E. A. (1986). Pharmacology of lemongrass (Cymbopogon citratus Stapf). II. Effects of daily two month administration in male and female rats and in offspring exposed "in utero". J Ethnopharmacol, 17(1), 65-74. https://doi:10.1016/0378-8741(86)90073-5 DOI: https://doi.org/10.1016/0378-8741(86)90073-5
  68. Subebe, M. J., Ogaro, J. C., Dayon, M. L., Manting, M. E., Murashima, A., Omori, A., & et al. . (2024). Phytochemical evaluation, embryotoxic, and teratogenic effects of Buwakan (Decalobanthus peltatus (L.) A.R.Simões & Staples) leaf extracts on duck embryo. Environ Anal Health Toxicol, 39(1), e2024004-0. https://doi:10.5620/eaht.2024004 DOI: https://doi.org/10.5620/eaht.2024004
  69. Teshome, D., Tiruneh, C., Berhanu, L., Berihun, G., & Belete, Z. W. (2021). Developmental Toxicity of Ethanolic Extracts of Leaves of Achyranthes aspera, Amaranthaceae in Rat Embryos and Fetuses. J Exp Pharmacol, 13, 555-563. https://doi:10.2147/JEP.S312649 DOI: https://doi.org/10.2147/JEP.S312649
  70. Unsworth, B., Hennen, S., Krishnakumaran, A., Ting, P., & Hoffman, N. (1974). Teratogenic evaluation of terpenoid derivatives. Life Sciences, 15(9), 1649-1655. https://doi.org/10.1016/0024-3205(74)90331-2 DOI: https://doi.org/10.1016/0024-3205(74)90331-2
  71. Uysal, H., Kara, A. A., Algur, O. F., Dumlupynar, R., & Aydogan, M. N. (2007). Recovering Effects of Aqueous Extracts of Some Selected Medical Plants on the Teratogenic Effects During the Development of D. melanogaster. Pakistan Journal of Biological Sciences, 10(10), 1708-1712. https://doi:10.3923/pjbs.2007.1708.1712 DOI: https://doi.org/10.3923/pjbs.2007.1708.1712
  72. Valadez-Alvizo, R., Rodríguez-Alvarado, A., Martínez de Villarreal, L., González-Alanís, R., & Piñeyro-López, A. (1993). Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse. Toxicon, 31(10), 1329-1332. https://doi.org/10.1016/0041-0101(93)90406-9 DOI: https://doi.org/10.1016/0041-0101(93)90406-9
  73. Vohora, S. B., Garg, S. K., & Chaudhury, R. R. (1969). Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res, 57(5), 893-9. Link
  74. Wachtel-Galor, S., & Benzie., I. F. (2011). Herbal Medicine. In F. L. Boca Raton, I. F. Benzie, & S. Wachtel-Galor (Eds.), Herbal Medicine: Biomolecular and Clinical Aspects (2nd ed.). CRC Press/Taylor & Francis. Retrieved from Link