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Abstract

In developing countries such as Afghanistan, cancer is the second leading cause of death in humans. Primary liver cancer accounts for approximately 4% of all newly diagnosed cancers worldwide. Around 80% of all liver malignancies globally are hepatocellular carcinomas (HCC). Several factors, including the hepatitis B and C viruses, are involved in the development of liver cancer. In recent years, mycotoxins have contributed to the development of hepatocellular carcinoma in both humans and the majority of domestic and laboratory animals. Among mycotoxins, aflatoxin, and especially aflatoxin B1, is the most well-known carcinogenic agent of hepatocellular carcinoma, classified as group 1 carcinogen by the International Agency for Research on Cancer (IARC). The aim of this review is to look into the carcinogenesis of aflatoxins and how they relate to hepatocellular carcinoma.

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Aflatoxin Hepatocellular carcinoma Animals Carcinogenesis Risk factors

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Sangary, M. . (2025). An Overview on the Role of Aflatoxin in the Development of Hepatocellular Carcinoma. Journal of Natural Sciences – Kabul University, 6(4), 193–206. https://doi.org/10.62810/jns.v6i4.349
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References

  1. Alkhayyat F, Yu J. Upstream Regulation of Mycotoxin Biosynthesis [Internet]. 1st ed. Vol. 86, Advances in Applied Microbiology. Copyright © 2014 Elsevier Inc. All rights reserved.; 2014. 251–278 p. Available from: http://dx.doi.org/10.1016/B978-0-12-800262-9.00005-6
  2. Ferrante M, Sciacca S, Gea OC. Carcinogen Role of Food by Mycotoxins and Knowledge Gap. 2012;(June).
  3. Bbosa GS, Kitya D, Lubega A, Ogwal-okeng J, Anokbonggo WW, Kyegombe DB. Review of the Biological and Health Effects of Aflatoxins on Body Organs and Body Systems. In p. 239–45.
  4. Marchese S, Polo A, Ariano A, Velotto S, Costantini S. Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development. Toxins (Basel). 2018;10(6):1–19.
  5. Claeys L, Fervers B, Saeger S De, Romano C, Korenjak M, Boevre M De, et al. Mycotoxin exposure and human cancer risk : A systematic review of epidemiological studies. Compr Rev I N FOOD Sci FOOD Saf. 2020;19:1449–64.
  6. Cai P, Zheng H, She J, Feng N, Zou H, Gu J, et al. Molecular Mechanism of Aflatoxin-Induced Hepatocellular Carcinoma Derived from a Bioinformatics Analysis. Toxins (Basel). 2020;1–13.
  7. Bbosa GS, Kitya D, Odda J, Ogwal-okeng J. Aflatoxins metabolism , effects on epigenetic mechanisms and their role in carcinogenesis. Health (Irvine Calif). 2013;5(10):14–34.
  8. Hamid AS, Tesfamariam IG. Aflatoxin B1-induced hepatocellular carcinoma in developing countries : Geographical distribution , mechanism of action and prevention ( Review ). 2013;1087–92.
  9. Kimanya ME, Routledge MN, Mpolya E, Ezekiel N, Shirima CP, Yun Y, et al. Estimating the risk of aflatoxin-induced liver cancer in Tanzania based on biomarker data. PLoS One [Internet]. 2021;16(3):1–11. Available from: http://dx.doi.org/10.1371/journal.pone.0247281
  10. Salim M, Masroor MS, Parween S. An Overview on Mycotoxins Causing Cancer in Human. 2020;11(1000364):1–9.
  11. Benkerroum N. Chronic and Acute Toxicities of Aflatoxins : Mechanisms of Action. 2020;1:1–28.
  12. Santos NP, Colaço AA, Oliveira PA. Animal models as a tool in hepatocellular carcinoma research : A Review. 2017;
  13. Magnussen A, Parsi MA. Aflatoxins , hepatocellular carcinoma and public health. 2013;19(10):1508–12.
  14. Eaton DL, Gallagher EP. Mechanisms of aflatoxin carcinogenesis. 1994;
  15. Kew MC. A atoxins as a Cause of Hepatocellular Carcinoma. 2013;22(3):305–10.
  16. Kensler TW, Roebuck BD, Wogan GN, Groopman JD. Aflatoxin : A 50-Year Odyssey of Mechanistic and Translational Toxicology. 2011;120:28–48.
  17. Adam M, Adam A, Tabana YM, Musa KB, Sandai DA. Effects of different mycotoxins on humans , cell genome and their involvement in cancer ( Review ). 2017;1321–36.
  18. Mccullough AAK, Lloyd RS. Mechanisms Underlying Aflatoxin-associated Mutagenesis–Implications in Carcinogenesis. DNA Repair (Amst) [Internet]. 2019;1(77):76–86. Available from: https://doi.org/10.1016/j.dnarep.2019.03.004
  19. OurWorldinData. Causes of death, World, 2019 [Internet]. 2019. Available from: https://ourworldindata.org/grapher/annual-number-of-deaths-by-cause
  20. IARC. (2020). Cancer Today. WHO. https://gco.iarc.fr/today/online-analysis-pie?v=2020&mode=cancer&mode_population=continents&population=900&populations=4&key=total&sex=0&cancer=39&type=1&statistic=5&prevalence=0&population_group=0&ages_group%5B%5D=0&ages_group%5B%5D=17&nb_items=10&group_cancer=1&include_nmsc=1&include_nmsc_other=1&half_pie=0&donut=0#collapse-by_countryhttps:%2F%2Fwww.google.com