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Abstract

This article discusses the definition, history, characteristics, and properties of thiosemicarbazone ligands. These compounds exhibit significant biological activities, including antiviral, antifungal, antibacterial, antitumor, anticancer, antioxidant, and insulin-mimicking properties. Coordination of thiosemicarbazone ligands occurs through donor atoms such as sulfur, nitrogen, and sometimes a third donor atom. The study's findings indicate that the presence of amide, amine, and thione groups makes thiosemicarbazones potential polydentate ligands. The aim of this review, which employs a descriptive-analytical approach, is to provide a comprehensive definition of these ligands, discuss their characteristics, structural features, and coordination behaviors.

Keywords

Biological Cis/trans Isomerism Coordination Properties S-alkylthiosemicarbazone Tautomerism Thiosemicarbazone Ligands

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poladian, qumars, & Juyan, M. Y. (2025). Magnetic Domains Investigating the Structure, Characteristics, and Properties of Thiosemicarbazone Ligands. Journal of Natural Sciences – Kabul University, 5(3), 149–160. https://doi.org/10.62810/jns.v5i3.290
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