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Abstract

Brucellosis is one of the most common neglected zoonoses worldwide, with over 500,000 new cases reported annually from endemic regions. Abortion and production decrements are the main signs of brucellosis in animals, but it is a systemic disease with diverse signs and symptoms in infected humans. There are no effective vaccines against human brucellosis, but Rev-1, S19, and RB51 are effective and available Brucella vaccines that are widely used in small ruminants and cattle, respectively. The application of these vaccines has had significant impacts on controlling brucellosis in animals, which consequently reduces new cases of brucellosis in humans. However, vaccination with these live attenuated vaccines is accompanied by infection and, in some cases, severe clinical manifestations in vaccinated or susceptible animals and humans. Therefore, the development of new, effective, and safe vaccines for both animal and human brucellosis is a high-priority demand for health sectors worldwide.

Keywords

Animals Brucellosis Challenges Efficacy Humans Vaccines

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Samadi, . A. . (2025). Efficacy and Challenges of Brucellosis Vaccines in Control of Disease in Animals and Humans. Journal of Natural Sciences – Kabul University, 4(3), 11–28. https://doi.org/10.62810/jns.v4i3.237
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