Article Sidebar

Download
Statistic
Read Counter : 33

Main Article Content

Abstract

During the inflammatory process, several events occur, including capillary expansion, cell proliferation, differentiation, and the recruitment of immune system cells to the site of inflammation. But how do these events happen? Cytokines, which include chemokines, interferons, interleukins, lymphokines, tumor necrosis factor (TNF), colony-stimulating factors (CSF), and others, play a key role in these processes. These secretory materials induce or inhibit changes that develop during the inflammatory process. Cytokines bind to specific receptors on the surfaces of cells and are classified based on their functions in the immune system. They are produced by both immune and non-immune cells. Generally, pro-inflammatory cytokines play a significant role in initiating inflammation by causing capillary expansion, increasing permeability, and recruiting immune cells to the injury site. Conversely, anti-inflammatory cytokines inhibit most of these events to prevent excessive inflammation.

Keywords

Chemokine CSF Inflammation Interferon Interleukin TNF

Article Details

License

Copyright (c) 2024 Reserved for Kabul University.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite
Sangary, M. (2025). A Review of Cytokines and Their Role in Inflammation. Journal of Natural Sciences – Kabul University, 4(1), 183–194. https://doi.org/10.62810/jns.v4i1.202
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Liang PY, Diao LH, Huang CY, Lian RC, Chen X, Li GG, Zhao J, Li YY, He XB, Zeng Y. The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure. Reproductive biomedicine online. 2015 Dec 1;31(6):823-6.
  2. Oliveira CM, Sakata RK, Issy AM, Gerola LR, Salomão R. Cytokines and pain. Revista brasileira de anestesiologia. 2011 Apr;61(2):260-5.
  3. Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Front Biosci. 1997 Jan 1;2(1):d12-26.
  4. Mosevoll KA, Skrede S, Markussen DL, Fanebust HR, Flaatten HK, Aßmus J, Reikvam H, Bruserud Ø. Inflammatory mediator profiles differ in sepsis patients with and without bacteremia. Frontiers in immunology. 2018 Apr 6;9:691.
  5. Yu L, He J, Wang L, Yi H. Inflammatory profiles revealed the dysregulation of cytokines in adult patients of HFMD. International Journal of Infectious Diseases. 2019 Feb 1;79:12-20.
  6. Mohan H. Textbook of pathology. 7th ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd.; 2013. p.48.
  7. PORTH CM. Inflammation, the Inflammatory Response, and Fever. In Dickinson S, editor. Essentials of Pathophysiology. 4th ed. Philadephia: Wolters Kluwer; 2015. p. 59.
  8. Hegazi A. Factors affecting the antibacterial activity of chitosan-silver nanocomposite. Sherif H HA, Khalil SK. H., Hegazi AG., Khalil W A. and Moharram M A. IET Nanobiotechnol., 11 (Iss. 6), 731-737,(2017). Journal of Pharmacopuncture. 2017;20(2):112-8.
  9. Eik Filho W, Marcon SS, Krupek T, Previdelli IT, Silva MA, Bazotte RB. Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia. Brazilian Journal of Medical and Biological Research. 2016;49(8).
  10. Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq-Yap YH, Hezmee MN. The crucial roles of inflammatory mediators in inflammation: A review. Veterinary world. 2018 May;11(5):627.
  11. Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B, Ryan PC, Salcedo TW, Bannish G. Cytokines: the good, the bad, and the deadly. International journal of toxicology. 2015 Jul;34(4):355-65.
  12. Cheong YC, Ledger WL. Cytokines in health and disease. The Obstetrician & Gynaecologist. 2003 Jul;5(3):155-9.
  13. Commins SP, Borish L, Steinke JW. Immunologic messenger molecules: cytokines, interferons, and chemokines. Journal of Allergy and Clinical immunology. 2010 Feb 1;125(2):S53-72.
  14. Gallenga CE, Pandolfi F, Caraffa AL, Kritas SK, Ronconi G, Toniato E, Martinotti S, Conti P. Interleukin-1 family cytokines and mast cells: activation and inhibition. J Biol Regul Homeost Agents. 2019 Mar 21;33(1):1-6.
  15. Kumar V, K.Abbas A, C.Aster J. Inflammation and Repair. In: Kumar V, K.Abbas A, C.Aster J. Robbins Basic Pathology. 10th ed. Philadelphia, Pennsylvania 19103-2899: ELSEVIER; 2018. p. 69.
  16. Ackermann MR. Inflammation and Healing. In: Zachary, James F; McGavin, M Donald. (eds.) Pathologic Basis of Veterinary Disease. 5th ed. Riverport Lane: ELSEVIER; 2012. p. 109.
  17. ) Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest. 2000 Apr 1;117(4):1162-72.